Why should this effect prove so helpful to the depressed, addicted, and anxious? As Pollan explains it, these disorders are the result of mental and emotional “grooves” in our thinking that have become, as the DMN’s name suggests, default. We are how we think. The right psychedelic experience can level out the grooves, enabling a person to make new cerebral connections and briefly escape from “a rigidity in our thinking that is psychologically destructive.”

Source: LSD research: Michael Pollan’s How to Change Your Mind, reviewed.